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In one of our projects we discovered that ACE2-deficient mice show an increased melanin production in the skin. We have studied the physiological functions of ACE2 in transgenic and knockout animal models. Therefore, the interaction of the SARS-CoV2 spike protein with ACE2, which is essential for cell entry of the virus, became a valid antiviral drug target. Recently ACE2 was characterized as receptor for SARS-CoV2 causing COVID-19. However, later studies revealed other substrates of the enzyme, but also non-enzymatic functions of ACE2, such as aminoacid transport in the gut.
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Selected candidates will receive dedicated support from our group to write a strong proposal.Īngiotensin-converting enzyme 2 (ACE2) is a multifunctional protein, that was discovered as a carboxypeptidase, converting the vasoactive peptide Ang II to Ang-(1-7). We are looking for a postdoc (or recent PhD graduate) in pre-clinical research who considers applying for the MSCA Postdoctoral Fellowship 2021 call. Michael Bader Preclinical studies on the SARS-CoV2 receptor ACE2 as therapeutic target
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Some groups may offer various projects and have not described a specific project below in this case explore the research group’ s webpage. October 12 th : Deadline for submission of MSCA fellowship October 1 st: Deadline for completion of administrative formalities September 5 th: Deadline for proposal submission to Career Center/ Funding OfficeĪugust 17 th: The MDC webinar presenting application support, postdoc opportunities and life at MDC